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College Football Week 2 Picks and Best Bets

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College Football Week 2 Picks and Best Bets are here. Week 2 of college football will kick off on Friday, Sept.  6. We’re looking at the best bets and predictions with our Week 2 picks. 

Week 1 was wild in college football, with some blowout wins and huge upsets. We’ve seen some change in the AP Top 25 poll. As we move into Week 2, we look to keep the winning ways going!

We finished 3-1 in our Week 1 picks.

So, what are the college football Week 2 picks and best bets?

Week 2 Picks & Best Bets

Arkansas vs Oklahoma State

  • Spread
    Arkansas +8
  • Moneyline
    Arkansas +240 / Oklahoma State -300
  • Over/Under
    62.5
  • Game time
    Noon ET
  • Location
    Boone Pickens Stadium | Stillwater, Oklahoma
  • How to Watch
    ABC

Full Write-Up Here

The Prediction: Oklahoma State 34, Arkansas 27

Best Bets: Arkansas +8


Texas vs Michigan

  • Spread
    Texas -7.5
  • Moneyline
    Texas -300 / Michigan +240
  • Over/Under
    42.5
  • Game time
    Noon ET
  • Location
    Michigan Stadium | Ann Arbor, Michigan
  • How to Watch
    FOX

Full Write-Up HERE!

THE PREDICTION: Texas 27 – Michigan 13

The Best Bet: Texas -7.5


Iowa State vs. Iowa

  • Spread
    Iowa State +3
  • Moneyline
    ISU +120 / Iowa -141
  • Over/Under
    35.5
  • Game time
    3:30 p.m. ET
  • Location
    Kinnick Stadium | Iowa City, Iowa
  • How to Watch
    CBS

The Iowa Hawkeyes shook off a sluggish start in their season opener against Illinois State, ultimately dominating the Redbirds with a 40-0 victory. While the defense held steady throughout, the offense’s second-half surge truly sealed the win.

Next up, the Hawkeyes face a more formidable challenge as they prepare to host the Iowa State Cyclones in Week 2. Both teams enter the matchup with 1-0 records, with the Cyclones securing a 21-3 win over FCS opponent North Dakota in their opener.

Iowa State brings back a wealth of experience from last season but will be adjusting to a new offensive coordinator after Nate Scheelhaase’s departure to the NFL. Meanwhile, Jon Heacock’s defense remains as formidable as ever. This matchup will also provide a clearer picture of Iowa’s new offensive coordinator, Tim Lester, whose unit impressed with Cade McNamara throwing three touchdown passes in the blowout win.

Conversely, Cyclones quarterback Rocco Becht connected for two touchdowns against North Dakota, setting the stage for an intriguing in-state showdown.

While Iowa looked better on offense, it was still Illinois State. I’m still not convinced they’ve figured everything out, even with McNamara under center. Now they have their handful with an experienced offense. I’m surprised Iowa is favored in this one despite being at home.

 

Prediction: Iowa State 24, Iowa 16

Best Bet: Iowa State +3


Boise State vs. Oregon

  • Spread
    Oregon -19.5
  • Moneyline
    Oregon -1100 / Boise State +700
  • Over/Under
    61.5
  • Game time
    10:00 p.m.m ET
  • Location
    Autzen Stadium | Eugene, Oregon
  • How to Watch
    Peacock

A highly anticipated matchup in the Pacific Northwest is finally upon us. The Boise State Broncos will take on the Oregon Ducks in a game that could significantly impact both teams’ College Football Playoff hopes. With both squads aiming for a playoff berth, Saturday’s clash is poised to be a defining moment in their seasons.

The Ducks entered Week 1 ranked No. 3 in the AP Poll, but they slipped four spots despite securing a 24-14 victory over Idaho. Oregon led 14-0 at halftime but struggled to close out the game, needing a late touchdown from Tez Johnson to fend off the Vandals. The Ducks’ offense sputtered at times, with three punts, two turnovers on downs, a lost fumble, and a missed field goal—leaving plenty of room for improvement as they prepare for Boise State.

On the other side, Boise State also showed vulnerabilities in their 56-45 win over Georgia Southern. The Broncos’ defense struggled, allowing 461 total yards and trailing 30-28 midway through the third quarter. However, a strong finish, fueled by running back Ashton Jeanty’s record-breaking performance, helped them pull away. Jeanty, a redshirt junior, ran for a school-record 267 yards and six touchdowns, solidifying his status as a top prospect for the upcoming NFL Draft and a Heisman Trophy candidate.

The Broncos have a strong history against Oregon, winning all three previous meetings, including the infamous 2009 clash marked by a post-game altercation between LeGarrette Blount and Byron Hout. Their most recent victory came in 2017 when Bryan Harsin’s squad defeated Mario Cristobal’s Ducks 38-28 in Las Vegas.

I think Oregon flexes on offense and gets its first win over Boise State while proving to the rest of the country that it is a legitimate national title contender.

Prediction: Oregon 47, Boise State 17

Best Bet: Oregon -19.5

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